Comparison of the Bed-Igg Captured EIA HIV-1 Incidence Assay with the Who-Criteria for Identifying Recently HIV Infected Individuals for Enrollment in the HIVDR-TS
Background: With the advent of antiretroviral therapy (ART) in several developing countries, WHO has proposed that countries should monitor HIV drug resistance (HIVDR) based on a population-based threshold survey. The guideline uses age-criteria to identify newly infected individuals. The accuracy of such guideline has not been validated, however.
Objective: To compare the WHO criteria for identifying recently infected individuals with a biological marker HIV-1 BED incidence assay.
Methods: Individuals were enrolled from the VCT center, Addis Ababa, Ethiopia. Initial HIV screening was done based on current national Rapid HIV screening algorithm. Based on the WHO criteria, HIV-positive was classified as recently infected if less than 25years of age. Moreover the HIV-positive specimens were retested by two conventional EIA tests and discrepant results were confirmed by Western blot test. Then using the bio-marker HIV-1 BED incidence assay to classify the recent infection for comparison with the WHO-criteria.
Results: A total of 4492 individuals underwent VCT and screened for HIV. Of these 360 (8.0 %) were found to be HIV-positive; 64 (1.4%) were identified as recently infected based on the WHO criteria. Forty-two (0.93%) were identified as recently infected by the HIV-1 BED incidence assay, giving an estimated incidence of 2.36 % per year [95% CI, 1.7-3.1]. However, the strength of agreement between the WHO criteria and BED assay is considered to be poor to fair K=0.29 (95% CI, 0.11 – 0.47).
Conclusion: The concordance between WHO criteria and BED assay is low. This shows that whether the WHO criteria over estimate or the BED assay under estimates recent infection (or vice versa) is difficult to identify. In the absence of current gold-standard to decide which of the above criteria is more accurate, the need for identifying recent HIV infection for the purpose of population based studies is urgent.
Keywords
Authors
How to Cite
Download Citation
License
Copyright © 2021 The Author(s)
Similar Articles
- Bogale Desta , Abaineh Munshia, Desalegn Adisu, Alemayehu Abate, Seroprevalence of Hepatitis B Virus Infection among people Living with HIV Attending at the Dangila Health Center, Northwest Ethiopia , Ethiopian Journal of Health and Biomedical Sciences: Vol. 15 No. 2 (2025)
- Debasu Damtie, Dilaferahu Abebe , Dawit Tatek , Baye Gelaw , A Three-Year Retrospective Study on The Prevalence of HBV, HCV, and HIV Among Blood Donors At The University Of Gondar Hospital Blood Bank, North West Ethiopia , Ethiopian Journal of Health and Biomedical Sciences: Vol. 2 No. 2 (2010)
- Feleke Mekonnen, Tigist Engida, Yalemwork Gashaye, Yitayih Wondimeneh, Mulat Dagnaw, The Prevalence of Tuberculosis among HIV/AIDS Patients Attending the Art Clinic at Gondar Health Center, Northwest Ethiopia , Ethiopian Journal of Health and Biomedical Sciences: Vol. 9 No. 1 (2019)
- Fantahun Sirata, Mebrate Dufera, Girmaye Kenasa, Sero-prevalence of HBV and associated factors among HIV positive adults attending ART clinic at Nekemte Specialized hospital, Nekemte, Western Ethiopia , Ethiopian Journal of Health and Biomedical Sciences: Vol. 13 No. 2 (2023)
- Asressie M, Yigzaw K , Telake A, Survival and Predictors of the Survival of HIV-Infected Adult Patients Taking HAART at Hawassa University Referral Hospital , Ethiopian Journal of Health and Biomedical Sciences: Vol. 6 No. 1 (2014)
- Gizeaddis Belay Mersha, Hailu Getachew, Yosef Getachew, Aimro Tadese, Tigist Birku, Michael Gete, Tazeb Molla, Alemayehu Abate, Belay Bezabih, Gene Mutations Conferring for Second-Line Drug-resistant Tuberculosis in Amhara Region: Eight-years Retrospective Study , Ethiopian Journal of Health and Biomedical Sciences: Vol. 15 No. 1 (2025)
- Getahun Asres Aleme, Abebaw Gebeyehu, Clinical Improvement and Drug-Adverse Effects among Patients Taking Anti-Tuberculosis Drugs , Ethiopian Journal of Health and Biomedical Sciences: Vol. 2 No. 2 (2010)
- Melsew Yihunie Belay, Getahun Mengistu, Adugnaw Zeleke Alem, Tilahun Yemanu Birhan, Time to Recovery from Undernutrition and Its Predictors among Patients with Multidrug-Resistant Tuberculosis in Addis Ababa, Ethiopia , Ethiopian Journal of Health and Biomedical Sciences: Vol. 13 No. 2 (2023)
- Abilo Tadesse, Zewdu Hurissa, Clinical and Hematological Features and Treatment Outcomes of Visceral Leishmaniasis Patients Admitted To Gondar University Hospital , Ethiopian Journal of Health and Biomedical Sciences: Vol. 2 No. 1 (2009)
- Getu Degu Alene, Harmful Traditional Health Practices: A Cross – Sectional Survey among Under-Five Children in Dembia District, North-West Ethiopia , Ethiopian Journal of Health and Biomedical Sciences: Vol. 2 No. 2 (2010)
You may also start an advanced similarity search for this article.
Most read articles by the same author(s)
- Mengistu Endris, Getasew Walle, Belaynew Wassie, Mulugeta Aemiro, Ligabaw Worku, Simon G/tsadik, Takele Teklu, Wubet Birhan, Jemal Ali, Bemnet Amare, Martha Alemayehu, Belay Anagaw, Aschalew Gelaw, Beyene Moges, Yeshambel Belyhun, Wossenseged Lemma, Meseret Delelegn, Prevalence of Intestinal Parasites and Associated Risk Factors among Students of Atse Fasil General Elementary School Azezo, Northwest Ethiopia , Ethiopian Journal of Health and Biomedical Sciences: Vol. 3 No. I (2010)