Cytokine Response in Mono and Malaria-S. mansoni Co-Infected Individuals in Fincha Sugar Estate, Western Ethiopia
Background: In Ethiopia, where malaria parasite and Schistosoma mansoni infections are coendemic, the general public is quite vulnerable to both malaria and S. mansoni infections singly and concomitantly. However, data about immunological effects are lacking. The aim of this study was to assess the reciprocal effects of malaria- S. mansoni co-infections with a particular emphasis on immunological interactions.
Methods: A community-based cross sectional study was conducted in Finchaa Sugar Estate, western Ethiopia. Plasma was collected for cytokine assay and measurements of selected cytokines were performed using luminex IS 100 instrument. SPSS statistical software version 20 was used, and P-value <0.05 was reported as statistically significant.
Results: Of the three groups of infections (malaria, S. mansoni and malaria- Schistosoma mansoni co-infections), the levels of IL-10 and IL-4 were higher in co-infected individuals than in mono-infected ones.
Conclusion: This study showed that Plasmodium falciparum and S. mansoni co-infection reciprocally increase anti-inflammatory cytokine (IL-10). However, further studies are required to investigate how malaria and S.mansoni co-infections could reciprocally contribute to increased levels of anti-inflammatory cytokines IL-10 and IL-4.
Keywords
Authors
How to Cite
Download Citation
License
Copyright © 2019 The Author(s)
Similar Articles
- Teklu Bekele, Yonas Yilma, Abebe Bekele, Riedel’s Thyroiditis in an Ethiopian Patient , Ethiopian Journal of Health and Biomedical Sciences: Vol. 1 No. 1 (2008)
- Meheretie Kokeb, Teklu Bekele Legesse, Bacillary Angiomatosis in an Ethiopian Child: A Case Report , Ethiopian Journal of Health and Biomedical Sciences: Vol. 2 No. 2 (2010)
- Feseha Gebreselassie, Suleman Isa, Getahun Asres , Tuberculous Otitis Media in a 32 Year Old Ethiopian Woman , Ethiopian Journal of Health and Biomedical Sciences: Vol. 6 No. 1 (2014)
- Daniel Admassi, Biruk L. WAMISHO, The Maffucci Syndrome: A Rare Case Report , Ethiopian Journal of Health and Biomedical Sciences: Vol. 2 No. 2 (2010)
- Fantanesh Desalegn , Zeleke Abebaw , Mengistu Mekonnen, Binyam Tilahun, Importance of CRC In-Service Training on Implementation of Compassionate and Respectful Care Delivery, in Gondar Town Governmental Health Facilities Northwest Ethiopia , Ethiopian Journal of Health and Biomedical Sciences: Vol. 12 No. 1 (2022)
- Baye Gelaw, Bacteriophage Based Assay to Detect Mycobacteria in the Sputum of Tuberculosis Patients , Ethiopian Journal of Health and Biomedical Sciences: Vol. 6 No. 1 (2014)
- Biniam Kefiyalew, Tezera Tadele, Zeleke Mekonnen, Binyam Tilahun, Bethelhem Anteneh, Alemayehu Teklu, Community engagement platforms for Compassionate Respectful and Caring health service: challenges and opportunities, in Sululta district, Ethiopia , Ethiopian Journal of Health and Biomedical Sciences: Vol. 12 No. 1 (2022)
- Tadis Brhane, Telake Azale, Knowledge, Attitude, and Practice on Emergency Contraception and Associated Factors among Female Students in Gondar Town, Northwest Ethiopia , Ethiopian Journal of Health and Biomedical Sciences: Vol. 3 No. I (2010)
- Yigzaw Kebede, Gashaw Andarge, Tesfahun Melesse, Temesgen Azmeraw, Takele Tadesse, Yiforkir Tefera, Abebaw Gebeyehu, Tadesse Awoke, Kassahun Alemu, Sisay Yifru, Afework Kassu, Tefera Abula, Mengesha Admassu, Shitaye Alemu, Solomon Meseret, Digsu Negesse, Getu Degu, Solomon Mekonnen, Berihun Megabiaw, Wondwosen Zemene, Assefa Getachew, Belaynew Wassie, Solomon Amsalu, Mamo Wubshet, Mezgebu Yitayal, Fasil Tessema, Yihunie Lakew, Tariku Dejene, Ejigu Gebeye, Melkamu Birku, Yosef Fekadu, Population Dynamics in Dabat Health and Demographic Surveillance System Sites, Dabat District, Northwest Ethiopia: A Four-year Surveillance Report (2009 To 2012) , Ethiopian Journal of Health and Biomedical Sciences: Vol. 7 No. 1 (2015)
- Adane Nigussie, Lidia Gebiru, Dawit Muluneh, Binyam Tilahun, The role of Performance appraisal system on Compassionate, Respectful, and Caring health care delivery in Northwest Ethiopia: an implementation study , Ethiopian Journal of Health and Biomedical Sciences: Vol. 12 No. 1 (2022)
You may also start an advanced similarity search for this article.
Most read articles by the same author(s)
- Mulugeta Aemero, Berhanu Erko, Mogessie Ashenafi, Woldaregay Erku, Assessment on the Status of Salmonella and Schistosoma Coinfections in the Middle Awash Valley and Ziway, Ethiopia” , Ethiopian Journal of Health and Biomedical Sciences: Vol. 6 No. 1 (2014)
- Fantahun Sirata, Mebrate Dufera, Girmaye Kenasa, Sero-prevalence of HBV and associated factors among HIV positive adults attending ART clinic at Nekemte Specialized hospital, Nekemte, Western Ethiopia , Ethiopian Journal of Health and Biomedical Sciences: Vol. 13 No. 2 (2023)