Cytokine Response in Mono and Malaria-S. mansoni Co-Infected Individuals in Fincha Sugar Estate, Western Ethiopia
Background: In Ethiopia, where malaria parasite and Schistosoma mansoni infections are coendemic, the general public is quite vulnerable to both malaria and S. mansoni infections singly and concomitantly. However, data about immunological effects are lacking. The aim of this study was to assess the reciprocal effects of malaria- S. mansoni co-infections with a particular emphasis on immunological interactions.
Methods: A community-based cross sectional study was conducted in Finchaa Sugar Estate, western Ethiopia. Plasma was collected for cytokine assay and measurements of selected cytokines were performed using luminex IS 100 instrument. SPSS statistical software version 20 was used, and P-value <0.05 was reported as statistically significant.
Results: Of the three groups of infections (malaria, S. mansoni and malaria- Schistosoma mansoni co-infections), the levels of IL-10 and IL-4 were higher in co-infected individuals than in mono-infected ones.
Conclusion: This study showed that Plasmodium falciparum and S. mansoni co-infection reciprocally increase anti-inflammatory cytokine (IL-10). However, further studies are required to investigate how malaria and S.mansoni co-infections could reciprocally contribute to increased levels of anti-inflammatory cytokines IL-10 and IL-4.
Keywords
Authors
How to Cite
Download Citation
License
Copyright © 2019 The Author(s)
Similar Articles
- Jemal Ali, Huda Mohammed, Adugna Abera, Yohannes Mengistu, Beverley Singh, Adrian Puren, Dawit Wolday, Comparison of the Bed-Igg Captured EIA HIV-1 Incidence Assay with the Who-Criteria for Identifying Recently HIV Infected Individuals for Enrollment in the HIVDR-TS , Ethiopian Journal of Health and Biomedical Sciences: Vol. 5 No. 1 (2012)
- Segen Tekle, Feleke Moges, Zemene Tigabu, Alem Getaneh, Bacterial Profile and Their Antibiotic Resistance Patterns from Blood Culture and Associated Risk Factors in Intensive Care Unit at the University Of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia , Ethiopian Journal of Health and Biomedical Sciences: Vol. 10 No. 1 (2020)
- Dessie Tegegne, Aschalew Gelaw, Demeke Endalamaw, Getachew Ferede, Baye Gelaw, The association between ABO blood groups and norovirus infections among patients suffering from diarrheal disease in Northwest Ethiopia , Ethiopian Journal of Health and Biomedical Sciences: Vol. 14 No. 1 (2024)
- Amare Teshome Tefera, Nebiyou Bekele, Shegaye Shumet, Martha Solomon, Tigist Mulugeta, Dessie Abebaw, Prevalence and associated factors of periodontal disease in Ethiopia: systematic review and meta-analysis , Ethiopian Journal of Health and Biomedical Sciences: Vol. 15 No. 1 (2025)
- Getachew Belay, Mulat Dagnew, Awgechaw Ketema, Habtalem Mequanint, Alebachew Fasil, Belete Biadgo, Habtamu Wondifraw, Teklay Gebrecherkos, Diagnostic Performance Of Reagent Strips And Microscopy For The Diagnosis Of Urinary Tract Infection Among Pregnant Women At the University Of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia A Cross Sectional Study , Ethiopian Journal of Health and Biomedical Sciences: Vol. 9 No. 1 (2019)
- Azene Dessie , Amha Mekasha, Fikre Enquselassie, Pneumonia in Children at a University Hospital in Addis Ababa, Ethiopia: Analysis of Potential Risk Factors , Ethiopian Journal of Health and Biomedical Sciences: Vol. 6 No. 1 (2014)
- Adane Derso, Aberham Abere, Yalewayker Tegne, Gezahegn Bewket, Amare Kiflie, Prevalence and risk factors of Helicobacter pylori infection among Pregnant Women in Northwest Ethiopia , Ethiopian Journal of Health and Biomedical Sciences: Vol. 12 No. 2 (2022)
- Menberework Chanyalew, Abraham Aseffa, Morten Harboe, Joseph Olobo Okao, Asrat Hailu, Experimental Infections with Leishmania Aethiopica and Immune Response Analysis of Cercopithecus Aethiops , Ethiopian Journal of Health and Biomedical Sciences: Vol. 2 No. 1 (2009)
- Mizan Kindu, Emergence and spread of carbapenemase producing Gram negative bacteria in Ethiopia: a call for action , Ethiopian Journal of Health and Biomedical Sciences: Vol. 14 No. 2 (2024)
- Aschalew Gelaw, Detection of Rotarix Vaccine Viruses in Older Children with Acute Gastroenteritis, Northwest Ethiopia , Ethiopian Journal of Health and Biomedical Sciences: Vol. 11 No. 1 (2021)
You may also start an advanced similarity search for this article.
Most read articles by the same author(s)
- Mulugeta Aemero, Berhanu Erko, Mogessie Ashenafi, Woldaregay Erku, Assessment on the Status of Salmonella and Schistosoma Coinfections in the Middle Awash Valley and Ziway, Ethiopia” , Ethiopian Journal of Health and Biomedical Sciences: Vol. 6 No. 1 (2014)
- Fantahun Sirata, Mebrate Dufera, Girmaye Kenasa, Sero-prevalence of HBV and associated factors among HIV positive adults attending ART clinic at Nekemte Specialized hospital, Nekemte, Western Ethiopia , Ethiopian Journal of Health and Biomedical Sciences: Vol. 13 No. 2 (2023)