Cytokine Response in Mono and Malaria-S. mansoni Co-Infected Individuals in Fincha Sugar Estate, Western Ethiopia

Mebrate Dufera , Hans C.Aass , Nega Berhe , Beyene Petros , Berhanu Erko
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DOI: https://doi.org/10.20372/ejhbs.v9i1.266
Submitted: 2021-08-26 08:42:06
Published: 2019-09-10

Background: In Ethiopia, where malaria parasite and Schistosoma mansoni infections are coendemic, the general public is quite vulnerable to both malaria and S. mansoni infections singly and concomitantly. However, data about immunological effects are lacking. The aim of this study was to assess the reciprocal effects of malaria- S. mansoni co-infections with a particular emphasis on immunological interactions.

Methods: A community-based cross sectional study was conducted in Finchaa Sugar Estate, western Ethiopia. Plasma was collected for cytokine assay and measurements of selected cytokines were performed using luminex IS 100 instrument. SPSS statistical software version 20 was used, and P-value <0.05 was reported as statistically significant.

Results: Of the three groups of infections (malaria, S. mansoni and malaria- Schistosoma mansoni co-infections), the levels of IL-10 and IL-4 were higher in co-infected individuals than in mono-infected ones.

Conclusion: This study showed that Plasmodium falciparum and S. mansoni co-infection reciprocally increase anti-inflammatory cytokine (IL-10). However, further studies are required to investigate how malaria and S.mansoni co-infections could reciprocally contribute to increased levels of anti-inflammatory cytokines IL-10 and IL-4.

 

Keywords

co-infection cytokine Finchaa Sugar Estate Plasmodium falciparum Plasmodium. vivax Schistosoma mansoni Ethiopia

Authors

Mebrate Dufera

Department of Biology, Wollega University, Post Box No: 395, Nekemte, Ethiopia, P.O.Box: 395, Nekemte, Ethiopia, E-mail: mebratedufera@gmail.com

 

Hans C.Aass

Department of Medical Biochemistry, Oslo University Hospital, Ullevål, Norway, E-mail: H.C.Aass@medisin.uio.no

Nega Berhe

Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Post Box No: 1176, Addis Ababa, Ethiopia, Centre for Imported and Tropical Diseases, Oslo University Hospital-Ulleval. E-mail: nega.berhe.belay@gmail.com,

Beyene Petros

Department of Microbial, Cellular and Molecular Biology, Addis Ababa University, Post Bo No: 1176, Addis Ababa, Ethiopia. E-mail: abule2002@gmail.com

Berhanu Erko

Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Post Box No: 1176, Addis Ababa, Ethiopia. E-mail: berhanue@yahoo.com

 

How to Cite

Mebrate Dufera, Hans C.Aass , Nega Berhe , Beyene Petros , Berhanu Erko (2019-09-10). Cytokine Response in Mono and Malaria-S. mansoni Co-Infected Individuals in Fincha Sugar Estate, Western Ethiopia. Ethiopian Journal of Health and Biomedical Sciences, Vol. 9 No. 1 (2019), 93-103. https://doi.org/10.20372/ejhbs.v9i1.266

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Copyright © 2019 The Author(s)

Copyright & Licensing © Year The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0) , which permits unrestricted use; sharing (copying and redistributing the material in any medium or format); and adaptation (remixing, transforming, and building upon the material for any purpose), provided the original author(s) and the source are properly cited/credited and a link to the license is provided. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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